How to Build a Protein
Jin Montclare’s lab designs and generates many types of proteins, including one that has been created to detoxify neurotoxins safely.
The proteins she builds are first visualized in three dimensions and generated computationally. This graphic illustrates the process.
This ribbon diagram pFF-PTE pFF-F104A shows a three-dimensional structure of a protein called phosphotriesterase, the protein Montclare is engineering to neutralize certain poisons and pesticides. It’s shown in two colors because it is a dimer, with two sub-units. Note that this protein is not visible to the eye or with a conventional microscope as it is nanometersized; that’s why these proteins are rendered computationally.